Monday, March 25, 2013

WatchESPN streaming reaches AT&T U-verse subscribers

WatchESPN reaches AT&T Uverse subscribers

U-verse subscribers often have some bandwidth to spare; it's only fair that they make the most of it with some streaming sports. Appropriately, AT&T and ESPN have just flicked the switch on WatchESPN support for those who subscribe to U-verse TV service. As always, viewers can tune into live and on-demand content from a computer, an Xbox 360 (with an Xbox Live Gold subscription) or their Android and iOS devices while on the road. The sports partnership is also just the start: AT&T notes that all flavors of Watch Disney should be coming "soon," giving the little ones something to stream in between football matches.

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Source: WatchESPN

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/DGxtL5TX_hU/

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Editor's desk: GDC bound!

Editor's desk: GDC bound!

I'm up, up, and away later today for San Francisco, California and the Game Developer Conference (GDC 2013). I certainly don't have to tell anyone here how great the iPhone, iPod touch, and iPad are for gaming. Whether or not Apple "gets" gaming, they've enabled a lot of technology that a lot of developers have used to make great games. That's why, increasingly, iOS is a big deal in the gaming industry, and at events like GDC.

I'll be there along with our gaming editor Simon Sage, and Windows Phone Central's Paul Acevado. Our goal at the show is to get a better idea of where mobile gaming is going in 2013, get a look at some upcoming titles, and do our very best to bring you all with us. As always, the official stuff will go up right here on iMore, Android Central, CrackBerry, and Windows Phone Central, and if you want the behind-the-scenes shenanigans, you should follow us on Twitter @reneritchie, @simonsage, and @segacon.

Because I'm flying today, I recorded the iMore show on Friday, and with Dieter Bohn from the Verge to boot. (Dieter started the show way back in 2007, and the first podcast I ever did was with Dieter, so it was great to have him back on.) He's one of the mightiest minds in mobile, and the show was a blast, so if you haven't already, check it out.

We've also got what might be the biggest episodes of Debug in the history of Debug coming your way Monday, so make sure you check back here in the morning. You won't want to miss it.

Don't forget, iMore is looking for a full-time assistant editor, so if that's you, make sure you check it out.

We've gotten a ton of applications already, but since I'll be away, we won't even be able to start going through them until next week. That means there's still plenty of time. Also, We may also be looking for a few more part-time writers in the near future, so if you don't have the experience necessary to help run a site like iMore -- and frankly, that skill set isn't too common yet -- there'll be ways to get a start too. More on that soon!

Also, If you're a developer, designer, gamer, or iMore reader in SF, don't hesitate to say hello. I'd love to talk to you.

Now, up up and away!



Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/f0uBKrozRv0/story01.htm

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Sunday, March 24, 2013

First generation ASUS Padfone gets bumped up to Jelly Bean

ASUS Padfone

While we may be waiting on the arrival of the new ASUS Padfone Infinity, it could be easy to forget about the first generation Padfone. The one that started it all for ASUS and their phone/tablet hybrid range first properly appeared back at MWC 2012, but ASUS sure hasn't forgotten about it. An update is now available for the device which bumps it up to Android 4.1.1 Jelly Bean. 

Currently, two variations on the update are out in the wild, a worldwide version and a Chinese version. There are a few ASUS specific improvements bundled in, such as improved File Manager, camera functions, scrapbook functions and supporting NTFS and EX FAT format SD cards. But, ultimately the headline is all about Jelly Bean, and the improvements it brings along such as Project Butter and Google Now. 

It's a hefty update, weighing in at 579MB, and download links for both versions can be found at the source link below. 

Source: ASUS



Source: http://feedproxy.google.com/~r/androidcentral/~3/ZKwV_Vysouk/story01.htm

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Wide range of potential outcomes on gay marriage

WASHINGTON (AP) ? The Supreme Court can choose from a wide array of outcomes in ruling on California's Proposition 8 ban on same-sex marriage and the federal Defense of Marriage Act.

The federal law, known by the shorthand DOMA, defines marriage as the union of a man and a woman and therefore keeps legally married gay Americans from collecting a range of federal benefits that generally are available to married people.

The cases will be argued Tuesday and Wednesday; rulings are not likely before late June.

The justices might come out with rulings that are simple, clear and dramatic. Or they might opt for something narrow and legalistic.

The court could strike down dozens of state laws that limit marriage to heterosexual couples, but it also could uphold gay marriage bans or say nothing meaningful about the issue at all.

A look at potential outcomes for the Proposition 8 case and then for the case about DOMA:

___

Q. What if the Supreme Court upholds Proposition 8?

A. This would leave gay Californians without the right to marry in the state and would tell the roughly 40 states that do not allow same-sex marriages that there is no constitutional problem in limiting marriage to a man and a woman.

Such an outcome probably would trigger a political campaign in California to repeal Proposition 8 through a ballot measure and could give impetus to similar voter or legislative efforts in other states.

___

Q. What if the court strikes down Proposition 8?

A. A ruling in favor of the two same-sex couples who sued to invalidate the voter-approved gay marriage ban could produce one of three possibilities. The broadest would apply across the country, in effect invalidating constitutional provisions or statutes against gay marriage everywhere.

Or a majority of the justices could agree on a middle option that applies only to California as well as Colorado, Delaware, Hawaii, Illinois, Nevada, New Jersey, Oregon, and Rhode Island. Those states already treat gay and straight couples the same in almost every respect through civil unions or domestic partnerships. The only difference is that gay couples are not allowed to marry. Gov. John Hickenlooper, D-Colo., signed his state's civil unions law Thursday.

This "nine-state solution" would say that the Constitution forbids states to withhold marriage from same-sex couples while giving them all the basic rights of married people. But this ruling would not implicate marriage bans in other states and would leave open the question of whether states could deprive gay couples of any rights at all.

The narrowest of these potential outcomes would apply to California only. The justices essentially would adopt the rationale of the federal appeals court that found that California could not take away the right to marry that had been granted by the state Supreme Court in 2008 before Proposition 8 passed later that year.

In addition, if the Supreme Court were to rule that gays and lesbians are deserving of special protection from discriminatory laws, it is unlikely that any state ban on same-sex marriage could survive long, even if the justices don't issue an especially broad ruling in this case.

___

Q. Are there other potential outcomes?

A. Yes, the court has a technical way out of the case without deciding anything about same-sex marriage. The Proposition 8 challengers argue that the private parties defending the provision ? members of the group that helped put the ban on the ballot ? did not have the right to appeal the trial judge's initial decision striking it down or that of the federal appeals court.

The justices sometimes attach great importance to this concept, known as standing. If they find Proposition 8's proponents lack standing, the justices also would find the Supreme Court has no basis on which to decide the case.

The most likely outcome of such a ruling also would throw out the appeals court decision that struck down the ban but would leave in place the trial court ruling in favor same-sex marriage. At the very least, the two same-sex couples almost certainly would be granted a marriage license, and Gov. Jerry Brown, D-Calif., who opposes Proposition 8, probably would give county clerks the go-ahead to issue marriage licenses to same-sex couples.

___

Q. Are the possibilities for the DOMA case as complicated?

A. No, although there are some technical issues that could get in the way of a significant ruling.

___

Q. What happens if the court upholds Section 3 of DOMA, defining marriage for purposes of federal law as the union of a man and a woman?

A. Upholding DOMA would not affect state laws regarding marriage but would keep in place federal statutes and rules that prevent legally married gay Americans from receiving a range of benefits that are otherwise available to married people. These benefits include breaks on estate taxes, health insurance for spouses of federal workers and Social Security survivor benefits.

___

Q. What if the court strikes down the DOMA provision?

A. A ruling against DOMA would allow legally married gay couples, or in some cases, a surviving spouse in a same-sex marriage, to receive benefits and tax breaks resulting from more than 1,000 federal statutes in which marital status is relevant. For 83-year-old Edith Windsor, a New York widow whose case is before the court, such a ruling would give her a refund of $363,000 in estate taxes that were paid after the death of her spouse, Thea Spyer.

___

Q. What procedural problems could prevent the court from reaching a decision about DOMA?

A. As in the Proposition 8 case, there are questions about whether the House Republican leadership has the right to bring a court case to defend the law because the Obama administration decided not to.

House Republicans argue that the administration forfeited its right to participate in the case because it changed its position and now argues that the provision is unconstitutional.

If the Supreme Court finds that it does not have the authority to hear the case, Windsor probably would still get her refund because she won in the lower courts, but there would be no definitive decision about the law from the nation's highest court and it would remain on the books.

___

Follow Mark Sherman on Twitter: http://twitter.com/shermancourt

Source: http://news.yahoo.com/wide-range-potential-outcomes-gay-marriage-135431574.html

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Saturday, March 23, 2013

Morocco Islamists struggle with coalition rule

RABAT, Morocco (AP) ? After just over a year in power, Morocco's Islamist-led government is struggling to fulfill the high hopes brought on by its election in 2011 on promises to fight corruption, provide for the needy and reform the country.

Working within a coalition of often reluctant allies, the moderate Islamists of the Justice and Development Party have found many of their initiatives blocked by an establishment with close ties to the royal palace that still wields ultimate power in this North African kingdom of 32 million.

Like the Islamist parties in Tunisia and Egypt, the PJD, as the Moroccan party is known, capitalized on the pro-reform demonstrations of the Arab Spring and swept into power through the ballot box. But also like their sister parties in the region they are finding ruling to be much more difficult than being in the opposition.

Morocco gained notice internationally for its swift response to defuse Arab Spring-inspired demonstrations in 2011, pledging reform and greater democracy. The constitution was quickly amended and early elections were held, resulting in a coalition of Islamists along with leftist and conservative parties that pledged to tackle some of the deep seated problems that had brought people into the streets by the tens of thousands.

The coalition, however, has shown signs of strain, with some members threatening to quit amid accusations that the Islamists are trying to monopolize power. Meanwhile there has been little headway in confronting Morocco's severe economic woes.

During recent by-elections, Prime Minister Abdelilah Benkirane, who leads the PJD, campaigned less on his record than on attacks against forces "plotting" his downfall. In January, he said at a conference that he wasn't sure he would be allowed to finish his five-year term.

The opposition, however, has said that such talk is just a way of covering up for the government's failures. In its first year, it has achieved relatively little, passing only five of the 20 laws meant to implement the democratic reforms of the new constitution.

Abdallah Bouanou, the head of the Islamists' parliamentary delegation, told The Associated Press that there are powerful forces in the administration, business world and opposition parties that oppose the government's ambitious reform agenda and want to undo Morocco's Arab Spring, which began on Feb. 20, 2011 ? something he warned that could spark renewed popular demonstrations.

"There are people who benefited from the despotism and corruption before Feb. 20," he said Wednesday. "They want to go back to before Feb. 20 and they don't respect the law or the (new) constitution."

He warned that if they succeeded the people, as well as his own party, would return to the streets. "If necessary the PJD would not hesitate to also go into the streets to protect the reforms and defend the constitution," he said.

The squabbles within the coalition and without come against a backdrop of an increasingly serious economic situation.

Official unemployment has risen to 9 percent and the deficit last year reached a higher-than-expected 7.1 percent of GDP.

International ratings agencies Moody's and Standard & Poor recently downgraded the country's outlook from stable to negative because of the worsening fiscal crisis, citing in particular the lack of progress on reforming a system of subsidies for fuel and food staples that costs the country $6.5 billion a year. The government announced that it would reform the massively expensive program taking up 6 percent of GDP by June and replace across the board subsidies with targeted aid to the most needy.

Moody's noted that the country only had $15 billion in hard currency reserves, just enough to cover four months of imports.

Morocco received help from the International Monetary Fund in August with a $6.2 billion precautionary credit line ? but the assistance comes on the condition that the subsidies and pensions system are reformed.

Paradoxically, some of the fiercest opposition to the PJD has come from its main coalition partner, the Istiqlal (Independence) Party, which has been a relentless critic of the Islamists since it elected a new leader, Hamid Chabat, in September.

In December, Chabat sent a memo to Benkirane demanding a Cabinet reshuffle and a greater role in decision-making for his party or he would pull out of the coalition. He accused the PJD of seeking to "Egyptianize" Morocco and rule with an unchallenged, dominant Islamist party.

The two party leaders patched up their differences in a meeting Feb. 15, but still ended up fielding competing candidates in by-elections two weeks later, in a continuing sign of their differences.

On Monday, Chabat again accused the Islamists of trying to monopolize the reform process, even as he made overtures to opposition parties, sparking rumors of a possible coalition reshuffle.

He also accused PJD ministers of "wanting to place their own people in all high level posts."

The PJD's Bouanou suggested that the Istiqlal's opposition stemmed from fears that if the Islamists succeeded in resolving some of the long-standing problems in the country, including corruption and a flawed justice system, it would make them unstoppable at the ballot box.

____

AP reporter Smail Bellaouali contributed this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-03-23-Morocco-Islamists'%20Challenge/id-776948c942ec4af4be937522988bd359

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Pain reliever shows anti-viral activity against flu

Friday, March 22, 2013

The over-the-counter anti-inflammatory drug naproxen may also exhibit antiviral activity against influenza A virus, according to a team of French scientists. The finding, the result of a structure-based investigation, is published online ahead of print in the journal Antimicrobial Agents and Chemotherapy.

New influenza vaccines must be developed annually, because the surface proteins they target mutate rapidly, the way cars used to get a whole new look every year. The researchers, led by Anny Slama-Schwok of the Institut National de la Recherche Agronomique, Jouy en Josas, France, found a much more stable, reliable target for anti-influenza activity. The so-called ribonucleoprotein complexes are necessary for replication, and the researchers realized they could target the nucleoprotein, preventing assembly of the complexes. Because of its vital function, the nucleoprotein is highly conserved, making it a good potential target for antiviral drugs.

The nucleoprotein's three dimensional structure, solved in 2006, provided the basis for searching for new drugs that could interfere with its action. The researchers did a virtual screening within the Sigma-Aldrich online catalog of biochemicals. That screening identified Naproxen, better known as the over-the-counter pain reliever Aleve, and as expected, it bound to the nucleoprotein, and impeded RNA binding, says Slama-Schwok. In further testing, it reduced the viral load in cells infected with H1N1 and H3N2 influenza A virus, and in mice it demonstrated a therapeutic index against influenza A that was superior to that of any other anti-inflammatory drug.

Specifically, naproxen blocks the RNA binding groove of the nucleoprotein, preventing formation of the ribonucleoprotein complex, thus taking the vital nucleoproteins out of circulation. The researchers write that naproxen is a lead compound for drug development that could be improved by tweaking the molecule to boost its ability to bind to nucleoprotein.

As an already approved drug, naproxen could become a treatment against influenza relatively quickly, the researchers write. Its status as a non-steroidal anti-inflammatory drug (NSAID), which inhibits the COX-2 pathway, as well as an antiviral would boost its efficacy.

###

N. Lejal, B. Tarus, E. Bouguyon, S. Chenavas, N. Bertho, B. Delmas, R.W.H. Ruigrok, C. Di Primo, A. Slama-Schwok, 2013. Structure-based discovery of the novel antibviral properties of Naproxen against the nucleoprotein of influenza A virus. Antim. Agents Chemother. Online ahead of print 4 March 2013 ,doi:10.1128/AAC.02335-12

American Society for Microbiology: http://www.asm.org

Thanks to American Society for Microbiology for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127405/Pain_reliever_shows_anti_viral_activity_against_flu

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